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As mentioned, a key component of spadin's rapid action might involve the activation of CREB, which may involve a specific link between CREB activation and hippocampal neurogenesis

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Missing doses or irregular timing disrupts this accumulation

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Longitudinal monitoring For continuous monitoring, digital biomarkers can dynamically track core motor symptoms (e.g., tremor, bradykinesia, gait, and posture), non-motor symptoms (e.g., sleep), and motor complications (e.g., motor fluctuations and dyskinesia) objectively at high frequencies over days to months [157, 181, 182, 190, 195, 196]