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So the theory is if we give that same signal, a hormone at a higher dose, we can overcome whatever that barrier is and it turned out to be true

Retrieved from: Moriggi, M

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Additionally, it is believed that the PPG neurons are not the only source of GLP-1 in the brain, as gut-derived GLP-1 has been implicated in satiety studies to exert its effects on the brain as well [52]