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Cell Metab 23:591601 Apovian CM, Aronne LJ, Bessesen DH et al (2015) Pharmacological management of obesity: an Endocrine Society clinical practice guideline
Endogenous antagonists and competitive ligands, including agouti signaling protein (ASIP) and defensin 3, modulate MC1R tone by lowering cAMP output, thereby counterbalancing melanocortin stimulation
In some cases, people might experience dizziness, headache, or an allergic reaction