Oral administration has shown GI-local effects in rodent studies and some systemic effects
Researchers are always recommended to start with a low dose within the indicated range and gradually increase as needed while carefully monitoring for any potential side effects
Quirico L, Orso F, Cucinelli S, Paradzik M, Natalini D,Centonze G, Dalmasso A, La Vecchia S
doi: 10.1530/JOE-16-0450 8 LeeSTsirbasAGoldbergRAMcCannJD
Objective measurements (EEG, cardiovascular, and respiratory parameters) and subjective ratings (visual analog scales, awakening times) showed, assessed by Mann-Whitney U test, a normalization of severely disturbed sleep to normal sleep patterns
Years Considered for Study 1.2.3