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Beyond their primary role in improving glycemic control in patients with T2DM, DPP-4 inhibitors also demonstrate different effects on bone metabolism [107], e.g
They found that for FDA approved GLP-1s for weight loss, liraglutide (Saxenda) and semaglutide (Wegovy), the percent of side effects reported was as follows: Nausea: 42.2% Diarrhea: 21.9% Vomiting: also 21.9% Constipation: 8.4% They report that although the incidence of side effects were similar among medications, semaglutide had the greatest risk of nausea, diarrhea, and vomiting, whereas liraglutide had the greatest risk of upper abdominal pain
Thus, if the cytosolic GSH concentration is approximately 7000 M, then the half life would be in the 23 hour range
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Phillips, S
While you are figuring out the optimal dose of GLP-1, common side effects like nausea, gastrointestinal (GI) discomfort, and acid reflux, can interfere with sleep onset and lead to more awakenings during the night (ref)
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