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Dulaglutide versus empagliflozin as add-on therapy to metformin and sulfonylurea in type 2 diabetes: a randomized pilot study with exploratory metabolomic and microbiome analyses
In a phase 2 clinical trial, CagriSema reduced HbA1c by 2.2% (p = 0.075) in comparison with semaglutide 2.4 mg alone [101]
In our study, we observed decreased levels of Tet1 mRNA and Tet hydroxylase activity
Summer heat can affect medication storage and injection comfort
I can plan for one consistent day each week, and knowing everything is ready makes it less stressful." Key Insight: Focusing on timing, routine, and access rather than the delivery method helps patients feel prepared and confident about adherence
Combining these therapies that target mesolimbic hedonic hunger and hypothalamic appetite regulation may synergistically affect weight loss
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