Gut microbial dysbiosis can increase exposure to bacterial components and inflammatory stimuli, which may promote local innate immune activation and oxidative stress, and create a permissive microenvironment for -synuclein misfolding and aggregation [327, 328]
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Conversely, inhibition of PDE10A also activates cAMP/PKA signaling in the striatonigral (direct) pathway, resulting in the activation of thalamocortical circuits and replicating the effects of a D1-agonist
Mild injection site irritation, fatigue, or headache are the common side effects, but they can vary in people
These forward-looking statements can be identified by the use of forward-looking terminology, including the words anticipates, expects, intends, plans, decides, may, will, likely, potential, future, coming, hope, or should, or, in each case, their negative or other variations or comparable terminology
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