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doi:10.1056/NEJMe1611057 This editorial discusses the findings of the SUSTAIN-6 trial regarding semaglutide and cardiovascular outcomes, including potential implications for blood pressure management

It works by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

Users have shared reports of: Less joint stiffness during movement More comfort following workouts Decreased post-meal bloating Enhanced sense of physical "balance" or reduced localized tension Again, these outcomes are based on anecdotal accounts and are not guaranteed

There are now 6 GLP1-RAs approved for use in Australia with a number of them on the PBS for the management of hyperglycaemia in type 2 diabetes (T2D)

While NICE guidance (TA1026) recommends the medication, simply having a high Body Mass Index (BMI) does not automatically qualify you for an NHS prescription

The anti-doping agency USADA has issued specific warnings about BPC-157, calling it an "experimental peptide" with insufficient safety data