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Avoid administration during or immediately after intense exercise

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Hormone Research, 53(6), 274278

Mild nausea or a temporary drop in blood pressure

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

A syringe that is too large for a small dose can be difficult to control, while a syringe that is too small for a large dose may require multiple injections, causing unnecessary discomfort