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It adds that metformin dosing has to be revisited as renal function declines, which is a clinical judgment for your prescriber rather than a change to make yourself
This is why the dietary recommendations for semaglutide emphasize starting dietary changes before or simultaneously with medication initiation
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If the most uncomfortable period falls within the first four to eight hours after injection, and you inject at 8 PM or 9 PM, then the peak discomfort window aligns with your sleeping hours