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However, optimal doses appear tissue- and application-specific, with lower doses often sufficient for gastrointestinal applications while musculoskeletal injuries may benefit from higher dosing

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While these differences were not significant ( p = 0.094), the trend is potentially informative of what may be happening in the muscle in fatigue related disorders

Participants were male and female adults aged 18 years who were of non-childbearing potential and met the BMI inclusion criteria of either 30.0 kg/m, or 27.0 kg/m with hypertension or dyslipidemia

This is particularly beneficial in places like Australia, where cost-efficiency is as much a priority as it is a necessity

The review stresses that while promising, large RCTs are missing