After the metabolite dataset was scaled by log 2 transformation and z-score normalization algorithm, data was randomly split into the training dataset and the testing dataset
Unlike classic dietary antioxidants (vitamin C, vitamin E) which localize to specific compartments, melatonin being both lipophilic and hydrophilic distributes through all cellular compartments, especially concentrating in mitochondria where the majority of ROS are produced
Supplementing with D3 can improve serotonin levels, potentially alleviating mood swings or feelings of depression
Branded Ozempic and Wegovy pens hide the math
XZ and GL designed experimental protocols, interpreted data obtained from the experiments, and wrote the manuscript
While acknowledging the strengths of the study, such as participant criteria, low drop-out rates and high adherence, the researchers also acknowledged limitations, including the relatively short intervention duration and the absence of a third intervention group receiving synbiotics alongside a placebo