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Researchers have found that more than half of patients with hypothyroidism had muscle complaints, with 54 percent experiencing muscle weakness and 42 percent experiencing cramps

10.1016/j.cellsig.2017.09.004 172 PreziusoF.GenoveseS.MarchettiL.Sharifi-RadM.PalumboL.EpifanoF.et al (2020)

Key expectations for long-term treatment include: Weight loss velocity decreases over time, with most reduction occurring in the first 912 months Plateaus lasting 48 weeks are common and do not indicate treatment failure Individual response varies based on genetics, baseline metabolic health, adherence, and lifestyle factors Continued medication use is typically necessary to maintain weight loss Non-scale victoriesimproved mobility, reduced medication burden for comorbidities, better quality of lifeare equally important outcomes Patients should also be aware of potential adverse effects that may affect long-term adherence

The most common adverse events for those receiving tirzepatide were gastrointestinal-related and mild or moderate in severity

This finding supports results of several prior trials that showed GLP-1 medications reduce multiple major causes of mortality, including cardiovascular disease, kidney disease and diabetes, Mavromatis said