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We previously reported significantly increased ROS levels in the sera and livers of HCV-infected tree shrew, which is an emerging small animal model of the Tupaiidae family susceptible to HCV infection 56,57
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p53 is activated upon genotoxic and oxidative stress, which activates AMP-responsive protein kinase (AMPK) through the tuberous sclerosis (TSC) 1/TSC2 complex and inhibits mTOR activity to promote autophagy
S2CID 14555783
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Demonstrated this in a 1998 study showing that ipamorelin released GH in a dose-dependent manner in swine without elevating cortisol or prolactin at doses up to 1 mg/kg [1]
