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In addition, in order to achieve a plateau of efficacy (80% E max ), 2 g/day l-carnitine was required for at least 2 weeks
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Advanced stage , where cartilage has completely eroded, causing bone-on-bone friction, joint deformity, muscle atrophy, and chronic synovitis
These types of reactions often look like small red spots or a mild heat-like rash and usually subside as the body finds its new balance
Similarly, toxicity can be observed in the kidneys and may lead to acute renal failure (Bessems 2001
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