Yet in the most recent month, from June to July 2025, AOM semaglutide prescribing increased by 4.9%, the largest one-month gain in first-time AOM semaglutide prescribing in over a year
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Intriguingly, a phase 2B clinical trial of tirzepatide in people with diabetes and obesity suggested that this analogue, at the highest doses tested, has superior effects on glycaemia in comparison to the benchmark GLP-1 analogue dulaglutide (reductions in HbA1c of 1.9% vs
While studies indicate no significant interactions, the unique mechanisms of these drugs complicate our understanding of their combined efficacy
Importantly, the effect of this GLP-1R antagonist suggests local release of GLP-1 during OGTT