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Specific to cardiovascular-related death, ELIXA and SUSTAIN-6 trials showed similar performance relative to the placebo [ HR = 0.98 (95% CI 0.781.22) and HR = 0.98 (95% CI 0.651.48), respectively]
The quality of your starting material is the ceiling for the quality of your results
Results: Of the 33 patients evaluated for treatment efficacy, the objective response rate (ORR) and disease control rate (DCR) were 30.3% (10/33) and 75.8% (25/33), respectively, with 1, 9, 15, and 8 patients experiencing complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD), respectively
At the 0.25 milligram dose, you begin activating these same brain receptors, though the effect magnitude is typically more modest than at higher maintenance levels like 1.0 or 2.4 milligrams