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The next GLP-1 indicated for type 2 diabetes to lose exclusivity is Trulicity (dulaglutide) in 2027
These results suggest that basal Gs activation or GLP-1-stimulated Gs activation enhances insulin secretion, relying on protein A kinase and EPAC signals in GLP-1R-MIN-6 cells
that causes shrinking of the guard cells which results in stomatal closure (Mittler and Blumwald 2015)
it's a reflection of the funding economics of unpatentable compounds
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The molecular formula is CHCuNO with a molecular weight of approximately 403.9 Da
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