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698 Boudou, P
A decrease in body weight, blood pressure, HbA1c, fasting insulin, insulin resistance, plasma glucagon, total cholesterol, lipids, FPG, SMBG, cardiovascular death, nonfatal stroke, and myocardial infarction are observed with the use of semaglutide in monotherapy or in combination with other antidiabetic drugs
Peptides 77, 2127
Since tolerability remains a hurdle in the widespread adoption of GLP-1 treatments, experts at the summit discussed the potential of these combination therapies to mitigate treatment side effects and improve patient adherence
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Research has indicated that the -KG-consuming protein Tet3 (the primary -KG-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and then into 5-formyl- and 5-carboxy-dC) reroutes mitochondrial GDH, which converts glutamate into -KG in an NAD + -dependent manner, to the nucleus, indicating the onsite production of -KG
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