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Thiamine stores are relatively small as it's a water soluble vitamin, so worth keep in mind in patients who develop any initial nonspecific neurological symptoms

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The genes downregulated with semaglutide were significantly enriched in SMAD3 transcription factor motifs, an effector of canonical TGF signalling, as well as ZNF322 and NFY motifs, transcription factors responsive to noncanonical TGF signalling, consistent with the semaglutide-induced decrease in TGF signalling also observed in cardiac myocytes and fibroblasts

This guide is educational and not an endorsement of human use