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The primary endpoint will be bodyweight change (week 80 and 104), change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in the OA subset, and change in Apnoea-Hypopnea Index (AHI) in the OSA subset

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In order to minimise the variability in hormone levels and other factors that might affect the pharmacokinetic response, only male subjects were included in the current trials