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Although we have previously established that glutamine depletion reduces the antitumor effects of aspirin in PIK3CA -MT colorectal cancer and that aspirin promotes glutamine metabolism 21 , the underlying mechanisms for the favorable response to aspirin in PIK3CA -MT colorectal cancer remain unclear
ALC plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facilitating the transfer of fatty acids from cytosol to mitochondria during beta-oxidation in animals [15]
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Harb AA, Shechter A, Koch PA, St-Onge MP
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