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Mechanistically, the antibodies simultaneously engage EGFR/ERBB2 on tumor cells and the NKG2D-CAR on NK cells, establishing close-range immune synapses that directly activate CAR-NK cells irrespective of endogenous NKG2D-ligand expression, thereby overcoming target-recognition loss [81]

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A recent study implicates a role of miRNA in Rett syndrome through regulation of IGF-1 (Mellios et al., 2014)

HUBERMAN: And the first thing is that injury seems to be important