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200 Hypertension and its mechanism Hyperuricemia may acutely influence blood pressure through a renin-dependent pathophysiological mechanism
The solution is simple: start low and go slow
This is the same logic that makes the sildenafil-nitrate combination contraindicated: the FDA label for Viagra states that "administration of Viagra to patients who are using organic nitrates in any form is contraindicated" because of "potentiation of the hypotensive effects of nitrates" [3]
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