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The cost is pharmacologic surface area: more pathways engaged means more systems that can produce unwanted effects, and glucagon receptor agonism in particular has to be balanced carefully against the glucose-lowering arms of the molecule
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Under the Medicare Part D outpatient prescription drug benefit program, Part D plans are required to cover a minimum of two drugs in each therapeutic category and class, but from the outset, Medicare has been prohibited by law from covering medications when used specifically for weight loss
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