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Zepbound achieves 18-22% body weight reduction at 72 weeks, compared to Saxenda's 5-8% at 56 weeksoften roughly 2-3 times more in higher-dose trials, though results vary by individual and diabetes status
doi: 10.1038/tp.2016.145CrossRefGoogle ScholarPubMed Rush, A
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Contrave is contraindicated in people with seizure disorders, eating disorders (bulimia or anorexia), uncontrolled hypertension, or chronic opioid use
Moreover, there was no difference in weight changes between exenatide and abiglutide, and both were shown to exhibit remarkable weight loss effects (174)
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Large employers will have an option of paying more to retain coverage for weight loss
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