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Most patients experience some adjustment period lasting 24 weeks, though side effects vary widely based on individual metabolism and genetic factors

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doi: Stefan, M., Sharp, M., Gheith, R., Lowery, R., Ottinger, C., Wilson, J., Durkee, S

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As this was the first study manipulating TGF 1/SMAD3 signaling in these cells, it is possible that this signaling pathway could be generating other effects on these cells that have not been investigated, such as affecting junctional adhesion molecules or proteins of the adherens junction