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In particular, the improvement of therapeutic half-life 5 through incorporation of non-natural amino acids, D-amino acids, PEGylation, N- and C-terminal modifications, and attachment on the side chains has afforded an extended therapeutic window of activity in vivo , leading to dosing regimens that are comparable to those of small molecules

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Acute gallbladder disease or gallstones severe pain in your upper stomach, yellowing of skin or eyes, fever, or clay-colored stool

Gastrointestinal Effects The most frequent side effects involve your digestive system