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While heart palpitations specifically are not listed among the common adverse reactions in the FDA prescribing information for semaglutide products, increased heart rate is a documented effect, particularly with Wegovy

however, these observations are primarily based on in vitro and rodent models

Initial testing included laboratory tests to identify abnormalities in the respiratory chain, tricarboxylic-acid cycle (TCAC) and fatty-acid oxidation pathways

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Jan 22, 2026 Semaglutide and Heart Risk: What the Research Shows Can Ozempic (semaglutide) reduce cardiovascular risk

It also contains monounsaturated fats