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Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist
doi:10.1038/s41392-023-01481-w Neumaier F, Zlatopolskiy BD, Neumaier B
The glucagon component may also contribute to reduced hepatic lipid accumulation, which improves hepatic insulin sensitivity over time
These results have been successfully replicated in studies using other animal models
reported post-VSG increases in lumbar BMAT alongside peripheral MAT reductions, underscoring region-specific fatbone interactions, although other studies report a reduction in BMAT with VSG
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