The safety profile shows minimal adverse events, with injection site irritation occurring in less than 3% of female participants across multiple clinical trials
One key group includes individuals with pernicious anemia, an autoimmune condition that affects the bodys ability to absorb vitamin B12 from food
It creates a large demand on the body to make new glutathione

Immediate medical attention is required if patients experience concerning symptoms alongside the plateau, including: Unexplained fatigue, cold intolerance, or other symptoms suggestive of thyroid dysfunction Unintentional weight gain (rather than plateau) despite continued medication and lifestyle adherence New or worsening symptoms of depression or anxiety affecting motivation and self-care Severe abdominal pain (especially if radiating to the back) or persistent vomiting stop tirzepatide immediately and seek urgent medical attention to rule out pancreatitis Right upper quadrant or epigastric pain, fever, or jaundice, which may indicate gallbladder problems Symptoms of hypoglycaemia (sweating, dizziness, confusion, irritability) in patients also taking insulin or sulfonylureas Development of disordered eating patterns or unhealthy weight control behaviours Patients should also seek guidance if they are considering discontinuing Mounjaro due to plateau frustration
Offit Kurman
Providers often choose glycine for people who need digestive support or who report fatigue and poor recovery between doses