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(2024): Nicotinamide N-methyltransferase inhibition mitigates obesity-induced insulin resistance and hepatic steatosis
Additionally, increased SAM availability supports methylation reactions essential for epigenetic regulation and polyamine synthesis, influencing cellular differentiation and metabolic programming
Uofmhealth.org
The mechanism involves upregulation of matrix metalloproteinases (MMPs) and their inhibitors, which remodel collagen in a more organized way than unassisted healing
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