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Discussion In this cohort study, most patients with overweight or obesity discontinued GLP-1 RA therapy within 1 year, but those without type 2 diabetes had higher discontinuation rates and lower reinitiation rates

Severe obesity, uncontrolled diabetes, or subclinical hypothyroidism with minimal symptoms may justify early use of GLP-1s

The mechanism of action is that it passes through the hypothalamus, which controls these functions and often deals with diseases like clinical depression or anorexia nervosia

At 1 mg weekly, participants lost modest amounts

They prioritize long-term sustainable weight management

Nevertheless, research shows that it works by inducing the release of two important skin proteins: collagen and decorin [2]