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Oral tirzepatide is in development, and tirzepatide sublingual drops offer a needle-free option through some compounding pharmacies
One side effect of GLP-1 use can be dehydration, and of course, alcohol can compound the issue
doi:10.1038/s41586-024-07419-8 [4] Knudsen LB, Lau J
GLP-1 injections can cause side effects, so its recommended to start with a low dose and gradually increase it over time to reach the target dose
For patients meeting NICE criteria for weight management therapy (BMI 35 kg/m with adjustment for ethnicity, presence of weight-related comorbidities, and treatment through specialist weight management services), the dual benefit of weight reduction and blood pressure lowering may be particularly valuable
However, when combined with GLP-1 activation, glucagon effects shift dramatically toward beneficial metabolic outcomes
