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Additional Clinical Notes Documentation Essentials Diagnosis basis: history, impairment documentation, rating scales, collateral from school or workplace

6 The types of adverse events seen in TRIUMPH-1 and TRANSCEND-T2D-1 were generally consistent with trials of other incretin-based therapies

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Further, in vitro analysis observed that increasing doses of GLP-1 stimulate hypothalamic GnRH neurons by enhancing the mRNA levels of kisspeptin-1 (KISS-1), an HPG axis gatekeeper, together with increased GnRH mRNA expression, effects inhibited in the presence of a selective GLP-1R antagonist [141]

Although the exact mechanism of DPP-IV expression regulation remains poorly understood, TNF- has been implicated as one of the regulators (Duan et al