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However, compounded drugs are not FDA-approved and may be associated with higher safety concerns and product quality issues
33 Non-specific cysteine transporters While influx transporters are the main means by which cells acquire cystine, cysteine can also be taken up from the extracellular milieu into cells directly by excitatory amino acid transporter 3 (EAAT3) and the alanine-serine cysteine transporters 1 and 2 (ASCT1/2), all of which are known to be overexpressed in different cancer types 34 (Table 1)
If needed, changes to the maintenance dose should be made together with your healthcare provider
Beyond fibroblasts, glutamine metabolism affects other cell types relevant to fibrosis
It will be essential for voluntary licensing to enable access in low- and middle-income countries using generic formulations
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