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Efficacy The Wegovy pill has about the same efficacy as the 2.4 mg injectable formulation (the highest dose of Wegovy injection), according to the manufacturer: 14%-15% of starting body weight

lean mass +2.94%),15 with a clear superiority of SEMA 2.4 mg over LIRA 3 mg (15.8% vs 6.4%) as demonstrated in the STEP 8 study.16 The likelihood of reversal of diabetes by SEMA 2,4 mg was shown to be clearly superior to placebo in the STEP 10 study17 (Table 1)

However, this approach is not routine first-line treatment in UK practice, is considered off-label, and requires good patient adherence and clinical follow-up

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In preclinical research models, glucagon receptor agonism has been shown to reduce hepatic fat content and increase resting energy expenditure, effects that are preserved when glucagon agonism is combined with GLP-1R and GIPR activation [3]

Jude (Germaine-Munoz) Germaine, MD is a family physician in Springfield, New Jersey