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Short non-diabetic data support remaining at 2.5 mg when weight and insulin-resistance markers are already moving and tolerability favors a hold. The label still positions 2.5 mg as the starter before 5 mg, so it is a defensible low-dose floor for selected users rather than a replacement for the 5 mg obesity-trial floor

ulcer models Cutaneous wound healing, muscle regeneration, cardiac repair, ophthalmic research Transient local redness, mild fatigue, headaches (rare) Transient lethargy, local irritation, mild nausea Theoretical tumor risk from angiogenesis stimulation

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The most reliable indicator of degradation that does not show on visual inspection is reduced effectiveness

In diet-induced obese models, it produced a 7-10% reduction in body weight in just 11 days by increasing the basal metabolic rate