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Unfortunately, HIF-1 effectively promotes various immune suppressive pathways including secretion of immune suppressive cytokines, activation of myeloid-derived suppressor cells, activation of regulatory T cells, inhibition of T cells priming and activity, and upregulation of immune checkpoints

Rather, a broad-spectrum antimicrobial solution should be preferred if the risk of infection is higher

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However, the current literature lacks a comprehensive analysis that fully integrates the pathways of hypoxia, autophagy, and drug resistance