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Neurobiol Aging , 2005
Increased age is associated with conditions like elevated carotid intima-media thickness, carotid plaque, and carotid stenosis, which occur more frequently in older adults, compounding their CVD risk [447]
This process is called reconstitution
All of this happens before patients notice anything
So we can excrete HUGE amounts of B12 in a short time if it is extraneous to the amount we currently need
In vivo studies demonstrated that diabetic mice exhibit markedly lower hepatic LONP1 protein levels compared with lean mice, suggesting that LONP1 downregulation may contribute to the development of insulin resistance and type 2 diabetes [118, 119] (Fig
