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Jacamo R, Chen Y, Wang Z, Ma W, Zhang M, Battula VL, Schober WD, Davis RE, Konopleva M, Andreeff M

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In the presence of 1,25-dihydroxyvitamin D 3 , the VDR/RXR complex binds small sequences of DNA known as vitamin D response elements (VDREs) and initiates a cascade of molecular interactions that modulate the transcription of specific genes

It targets GLP1, GIP, and glucagon receptors simultaneouslyhence the third generation label after single (Ozempic) and dual (Mounjaro) agonists