The peptides specific targeting of NNMT-expressing adipocytes allows for a localized metabolic shift without widespread systemic overstimulation, presenting a unique model for selective fat mass modulation studies
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It is conceivable that in ASD, neuronal hyperexcitationconsistent with the excitatory-inhibitory imbalance hypothesistriggers compensatory excessive inhibition in specific brain regions, which may be reflected by elevated GABA concentrations
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5i) in either the Glp1r fl/fl or Glp1r Wnt1/ mice
(DAT, NET, and SERT) 10) By utilizing these transporters for its own uptake, amphetamine directly competes with endogenous dopamine, norepinephrine, and serotonin, thereby inhibiting their clearance from the synaptic cleft (Martin & Le, 2023)