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These statements are based on internal clinical observations and have not been evaluated by the Food and Drug Administration

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Reduced Progression of Degenerative Joint Disease Effective weight reduction may slow the progression of conditions such as: Knee osteoarthritis Lumbar facet arthropathy Degenerative disc disease 2

RNase H1treated DNA was used to confirm immunoprecipitation specificity, and siControl RNase H1untreated samples were set to 1. Gene expression analysis by quantitative RT-PCR Cells were washed with 1xPBS, and total RNA was prepared using Trifast (Euroclone) following manufacturers instructions