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Similarly, it has been shown that individuals with a higher Firmicutes abundance have a greater SCFA production capacity marked by increased acetate and butyrate productions (Reference Rahat-Rozenbloom, Fernandes and Gloor21 , Reference Aguirre, Bussolo de Souza and Venema139 , Reference Venkataraman, Sieber and Schmidt142 , Reference Turnbaugh, Ley and Mahowald148)
However, natural GLP-1 is quickly broken down by dipeptidyl peptidase 4 (DPP4) after it is released [2]
Discontinuation rates were higher with orforglipron than with placebo in both trials, and deaths were adjudicated as largely unrelated to treatment
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