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Therefore it is essential to investigate the effect of GSH depletion on RPE cells to further elucidate the potentially involved mechanisms

Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model

A recent study has demonstrated that an acute increase in the intracellular concentration of ROS inhibits the glycolytic enzyme pyruvate kinase M2 (PKM2) through the oxidation of Cys358 ( NRF2 INHIBITORS FOR ANTICANCER THERAPY Due to the multifaceted roles of Nrf2 in cancers, Nrf2 inhibitors could be effective for anticancer therapy

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