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3.1 Clinical studies of ferroptosis in neurodegenerative diseases Human biospecimen analyses revealed elevated agrin expression, reduced levels of platelet-derived growth factor receptor beta (PDGFR), type IV collagen, and fibronectin, pronounced small artery atherosclerosis and venous collagen deposition, and a reduction in pericyte numbers in the brain tissue of AD patients
RA: Data curation, Formal Analysis, Methodology, Software, Writing original draft
2009 Mar 9;169(5):502-7
Such findings are remarkable because it indicates that berberine can act on the level of pharmaceutical medications in certain regards
Further studies also suggest that the amino-acid sequence of GHK-Cu may have an antioxidative potential on ROS, such as hydroxyl radicals, and it may be even stronger than generic antioxidative peptides
GPx3 knockdown inhibits the proliferation and DNA synthesis and enhances the early apoptosis of human spermatogonial stem cells via mediating CXCL10 and cyclin B1
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