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A robust link between higher LCIG doses and reduced B12 levels in PwPD with PN has been pointed out with beneficial effect of vitamin B supplementation
This overwhelms the neuronal antioxidant defenses, causing oxidative damage to lipids, proteins, and DNA
For anyone dealing with chronic low-grade inflammation which is essentially 99% of people past mid-adulthood this systemic effect may be more valuable than mere cosmetic improvements
There is also the matter of accountability
Subcutaneous injection was chosen as 5A-1MQ specifically has poor oral bioavailability in mice, a phenomenon that does not occur in rats 26
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