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At higher doses (1.52mg), the incidence of gastrointestinal symptoms increases, and the theoretical risk of phosphate dysregulation becomes more relevant
Placebo doesnt eliminate bloating thats been consistent for months
Patient-dependent conditions affecting the effectiveness of treatment or, quite possibly, affecting outcomes through the gut microbiota, however, are still to be established
The market had changed enough by the time the institute revisited the topic in 2025 and found some drugs cost-effective at certain prices and formulations