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For example, weight reduction outcomes at 24 weeks were as follows: 1 mg : 7.2% 4 mg : 12.9% 8 mg : 17.3% 12 mg : 17.5% Placebo : 1.6% At 48 weeks, the differences became even more pronounced: 1 mg : 8.7% 4 mg : 17.1% 8 mg : 22.8% 12 mg : 24.2% Placebo : 2.1% The table below summarizes these outcomes, including the percentage of participants achieving clinically significant weight loss (5% and 15%) by dose level: Notably, doses of 8 mg and above achieved a 100% rate of clinically significant weight loss (5%) at 48 weeks, with the 12 mg dose leading to 83% of participants achieving 15% weight loss

Pessah-Pollack adds

A larger clinical trial randomly assigned more than 500 patients with type 2 diabetes and symptomatic peripheral neuropathy to one of the following treatments: (i) 600 mg/day of intravenous lipoic acid for three weeks followed by 1,800 mg/day of oral lipoic acid for six months, (ii) 600 mg/day of intravenous lipoic acid for three weeks followed by oral placebo for six months, or (iii) intravenous placebo for three weeks followed by oral placebo for six months (76)

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