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456 In the spinal cord, the influx of neuropathic signals to the dorsal horn leads to central sensitization, characterized by increased spontaneous neuronal activity, lowered activation thresholds for peripheral stimuli, heightened responses to sub-threshold stimuli, and expansion of receptive fields

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Preferred GLP-1 Receptor Agonists in Adults With Type 2 Diabetes and Established CVD or High CV Risk: A Network Meta-analysis of Randomized Trials